AlfaGene Bioscience, Inc.

AlfaGene is an innovative biotechnology company that uses its own novel proprietary cutting edge adult stem cell technology to create the only stem cell and non-transformed primary epithelial cell derived model of each segment of the entire gastrointestinal (GI) tract.

Gastrointestinal diseases affect millions of people, young and old all across the globe and cause heavy economical consequences for nations around the world. In the United States alone, GI diseases consume over $22 billion health care dollars annually with treatments that are usually not curative but just symptom relieving.  GI stem and epithelial cells are the main cellular component affected in the malignant transformation, inflammation, immune responses (e.g. autoimmune response), and disease of the GI tract, including:

  • colorectal cancer (CRC)

  • ulcerative colitis (UC)

  • Crohn's Disease (CD)

  • irritable bowel syndrome (IBS)

  • short bowel syndrome

  • gastroesophageal reflux disease (GERD) and Barrett’s esophagitis.

 AlfaGene Bioscience can isolate and culture human adult stem cells, which can be further differentiated to produce pure non-transformed primary epithelial cell type specific cell lines representative of the multiple epithelial cell types which line the GI tract, from both the disease affected and unaffected normal tissue of the same individual suffering any GI disease, infection, or malady.  The direct comparison of these paired cell lines facilitates the efficient rapid identification of cellular, molecular, genetic, and functional changes in stem and epithelial cells during disease development processes and thus allows identification of differentiating biomarkers, specific target molecules, and development of novel therapeutics.  These cell lines also provide superior cellular platforms for drug discovery and testing and form the basis for personalized immunogenic free stem cell therapies.

Company Mission